This dual-action formulation combines:
- Sildenafil Citrate (50-100mg): A PDE5 inhibitor that enhances blood flow to the penile region
- Duloxetine (30-60mg): An SNRI that helps regulate ejaculatory control
Clinical Indications:
- Erectile dysfunction (ED) caused by inadequate penile blood flow
- Premature ejaculation (PE)
- Sexual performance anxiety
Dosage & Administration
- Recommended dosage: 1 tablet daily
- Optimal timing: 30 minutes before sexual activity
- Administration guidelines:
- May be taken with or without food
- Swallow whole with water
- Strictly adhere to once-daily dosing
- Avoid alcohol consumption
Important Safety Considerations
Common Adverse Effects:
- Cephalalgia (headache)
- Epistaxis (nosebleeds)
- Dyspepsia (indigestion)
- Insomnia
- Gastrointestinal disturbances
- Dizziness
- Paresthesia (tingling/numbness in extremities)
Serious Adverse Reactions:
- Priapism (prolonged painful erection >4 hours)
- Visual disturbances/photosensitivity
- Hematuria (bloody urine)
- Tinnitus (ringing in ears)
- Urinary retention/dysuria
Critical Contraindications
- Concurrent use of MAO inhibitors
- Uncontrolled hypertension
- Severe hepatic/renal impairment
- Angle-closure glaucoma
- History of seizures
- Bipolar disorder
Drug Interaction Warnings
Absolute Contraindications:
- Nitrate medications
- Other PDE5 inhibitors
- Strong CYP3A4 inhibitors
Require Medical Supervision:
- SSRIs/SNRIs
- Anticoagulants
- Antihypertensives
- CNS depressants
Patient Counseling Points
- Report any erection lasting >4 hours immediately
- Discontinue if visual/hearing disturbances occur
- Monitor for mood changes/suicidal ideation
- Maintain adequate hydration
- Avoid hazardous activities if dizzy
- Does not prevent STDs/pregnancy
Storage Requirements:
- Store at 20-25°C (68-77°F)
- Protect from moisture and light
- Keep in original packaging
- Secure from children/pets
Note: This medication requires prescription and medical supervision. Regular follow-up recommended to assess treatment efficacy and safety profile. Not indicated for female or pediatric use.