Prednisone is a corticosteroid medication used to reduce inflammation and suppress immune system activity. It is prescribed for various conditions, including:

• Rheumatoid arthritis
• Severe asthma
• Allergic reactions
• Autoimmune disorders
• Certain skin conditions

Mechanism of Action

• Suppresses inflammation by inhibiting inflammatory mediators
• Modifies immune system responses
• Alters the body's reaction to immune stimulation

Dosage and Administration

• Take orally with or without food (taking with food may reduce stomach irritation)
• Typical daily dose ranges from 5-60 mg, adjusted based on condition and response
• For chronic conditions:
  • Initial high dose is gradually reduced to lowest effective maintenance dose
  • Long-term use requires gradual tapering to avoid adrenal insufficiency
  • Short-term therapy (under 1 week) may not require tapering

Important Precautions Before taking prednisone, inform your doctor if you have:

• Active infections (bacterial, viral, fungal)
• Diabetes or high blood sugar
• Heart disease or hypertension
• Liver or kidney disease
• Osteoporosis
• Mental health conditions
• Stomach ulcers or intestinal disorders
• Thyroid disorders
• Myasthenia gravis

Special Considerations

• May cause increased appetite and weight gain - monitor diet carefully
• Can affect growth in children - regular monitoring required
• Not recommended during pregnancy/lactation unless absolutely necessary
• Avoid live vaccines while taking prednisone

Contraindications Do not use prednisone if you:

• Are allergic to corticosteroids
• Have systemic fungal infections
• Are being treated for tuberculosis
• Have untreated serious infections

Potential Side Effects Serious (require immediate medical attention):

• Vision problems
• Swelling/rapid weight gain
• Severe depression or behavioral changes
• Blood in stool/vomit
• Pancreatitis
• Severe hypertension
• Low potassium levels

Common (report if persistent):

• Sleep disturbances
• Mood changes
• Skin thinning/easy bruising
• Slow wound healing
• Increased sweating
• Headaches/dizziness
• Digestive discomfort
• Fat redistribution

Drug Interactions Prednisone may interact with:

• Blood thinners (warfarin)
• Diuretics
• Diabetes medications
• Ketoconazole/rifampin
• Anticonvulsants
• NSAIDs (aspirin, ibuprofen)
• Cyclosporine

Missed Dose

• Take as soon as remembered unless close to next dose
• Never double the dose
• Maintain regular dosing schedule

Overdose Symptoms

• Severe skin thinning
• Excessive bruising
• Abnormal fat distribution
• Hormonal imbalances
• Adrenal suppression

Seek immediate medical help if overdose is suspected

Storage Instructions

• Keep at 15-25°C (59-77°F)
• Protect from light and moisture
• Store in original container
• Keep away from children and pets
• Do not use after expiration date

Important Notes

• Regular medical supervision is essential
• Do not stop treatment abruptly
• Carry steroid alert card if on long-term therapy
• Monitor for signs of infection carefully
• Report any unusual symptoms promptly

Always follow your healthcare provider's instructions regarding dosage, duration, and monitoring while taking prednisone. This information does not replace professional medical advice.