Sildalis is a combination medication for treating male sexual dysfunction, containing two active components:

• Sildenafil (100 mg) - promotes blood flow to the penis for erection
• Tadalafil (20 mg) - prolongs the duration of sexual activity

This dual-action formula provides:

• Onset of action within 20-30 minutes
• Effects lasting up to 36 hours

Dosage and Administration

• Take one tablet orally with water
• Should be consumed 20-30 minutes before sexual activity
• Maximum dosage: one tablet per 24 hours
• Not for daily use - only as needed

Important Administration Notes

• Does not require regular dosing schedule
• Missed dose is not applicable (single-dose medication)
• Avoid high-fat meals before taking as they may delay absorption

Contraindications Absolute contraindications include:

• Hypersensitivity to sildenafil or tadalafil
• Concurrent use of nitrates or nitric oxide donors
• Recent cardiovascular events (heart attack/stroke within last 90 days)
• Severe hepatic impairment (Child-Pugh class C)
• Severe hypotension (<90/50 mmHg)
• Retinal disorders (retinitis pigmentosa)

Special Precautions Use with caution in patients with:

• Cardiovascular disease (stable angina, heart failure)
• Mild-to-moderate hepatic/renal impairment
• Anatomical penile deformities
• Conditions predisposing to priapism
• Bleeding disorders
• Active peptic ulcer disease

Potential Drug Interactions

• Nitrates (absolute contraindication - risk of severe hypotension)
• Alpha-blockers (increased hypotensive effects)
• CYP3A4 inhibitors (ketoconazole, ritonavir) - may increase concentrations
• Antihypertensives (additive blood pressure lowering)
• Grapefruit juice (may increase drug levels)

Adverse Effects Common (1-10%):

• Headache
• Flushing
• Dyspepsia
• Nasal congestion
• Back pain/myalgia

Less common (<1%):

• Visual disturbances (blurred vision, light sensitivity)
• Dizziness
• Hypotension
• Palpitations

Serious (require immediate medical attention):

• Priapism (prolonged painful erection)
• Sudden hearing loss
• Severe cardiovascular events
• Non-arteritic anterior ischemic optic neuropathy

Storage Requirements

• Store at room temperature (15-30°C)
• Protect from moisture and light
• Keep in original packaging
• Ensure proper child-resistant storage

Patient Counseling Points

• Does not protect against sexually transmitted infections
• Requires sexual stimulation to work
• Avoid excessive alcohol consumption
• Report any erection lasting >4 hours immediately
• Inform all healthcare providers about Sildalis use

Important Safety Information

• Not recommended with other PDE5 inhibitors
• Cardiovascular status should be evaluated before prescribing
• Caution in patients taking strong CYP3A4 inhibitors
• Discontinue use if sudden vision/hearing loss occurs

This medication should only be used under medical supervision. Patients should undergo thorough cardiovascular assessment before initiation, especially those with multiple risk factors. Regular follow-up is recommended to monitor efficacy and adverse effects.