ABEC-L is an antiretroviral combination for:
- Management of HIV-1 infection in adults and adolescents
- Treatment of pediatric patients (>25 kg body weight)
- Viral load suppression and immune system support
Mechanism of Action
- Abacavir 600mg and Lamivudine 300mg are NRTIs
- Block HIV reverse transcriptase enzyme
- Prevent viral replication
- Increase CD4 white blood cell count
Dosage & Administration
- Take one tablet daily with/without food
- Swallow whole with water
- Do not crush or chew
- Continue treatment lifelong unless directed otherwise
Key Benefits
- Reduces viral load
- Slows HIV progression
- Improves immune function
- Convenient once-daily dosing
Important Safety Information
- Contraindications:
- HLA-B*5701 allele positive patients
- Hypersensitivity to abacavir/lamivudine
- Severe liver impairment
- Precautions:
- Regular monitoring required for:
- Liver/kidney function
- Blood lipids/sugar
- Body weight changes
- Not recommended during pregnancy/breastfeeding
Potential Side Effects
- Common:
- Headache/dizziness
- Nausea/diarrhea
- Insomnia
- Mild rash
- Serious (seek immediate care):
- Hypersensitivity reactions
- Lactic acidosis
- Severe hepatotoxicity
- Immune reconstitution syndrome
Drug Interactions
- Use caution with:
- Other NRTIs (emtricitabine, stavudine)
- Methadone
- Phenytoin
- Riociguat
- Sorbitol-containing products
Special Populations
- Children: Only for >25 kg under supervision
- Elderly: Requires dose adjustment
- Liver/kidney impairment: Close monitoring needed
Overdose Management
- Seek immediate medical attention if overdose occurs
Storage Instructions
- Store at room temperature
- Protect from moisture
- Keep in original packaging
Note: This treatment doesn't cure HIV or prevent transmission. Continue all preventive measures including safe sex practices. Regular medical follow-ups are essential.
