Abstet 250mg tablet is prescribed for:
- Metastatic castration-resistant prostate cancer (with prednisone)
Equivalent Brand
- Zytiga (US brand equivalent)
Mechanism of Action
- Contains abiraterone acetate
- Inhibits CYP17 enzyme to block testosterone production
- Slows prostate cancer progression
Dosage & Administration
- Standard dose: 250mg once daily
- Must be taken on empty stomach (1h before/2h after food)
- Always combined with prednisone
- Swallow tablet whole with water
Manufacturer
- Produced by Biocon Pharma
Important Safety Information
Contraindications:
- Severe liver impairment
- Pregnancy/breastfeeding
- Hypersensitivity to abiraterone
Precautions:
- Regular monitoring required for:
- Liver function
- Blood pressure
- Potassium levels
- Avoid alcohol
Potential Side Effects
Common:
- Joint pain/swelling
- Hot flashes
- High blood pressure
- Fatigue
- Digestive issues
Serious (seek medical help):
- Severe liver toxicity
- Heart rhythm abnormalities
- Adrenal insufficiency
Drug Interactions
- Avoid with:
- Strong CYP3A4 inducers (rifampicin, carbamazepine)
- CYP2D6 substrates (tamoxifen)
- Heart rhythm medications
Special Populations
- Not for use in women/children
- Elderly patients require close monitoring
Missed Dose/Overdose
- Missed dose: Skip if next dose is due soon
- Overdose symptoms: Dizziness, rapid heartbeat
Storage Instructions
- Store at room temperature (15-30°C)
- Protect from moisture and light
Note: Patients must use effective contraception during treatment. Regular blood tests are essential. Report any new symptoms to your oncologist immediately.
